Casts:
James FrancoTed RaimiVanessa FerlitoDylan BakerDaniel GilliesSam RaimiBill NunnCliff RobertsonKirsten DunstRosemary HarrisDonna MurphyTobey MaguireJ.K. SimmonsAasif MandviAlfred MolinaWillem Dafoe
Peter Parker is beset with troubles in his failing personal life as he battles a brilliant scientist named Doctor Otto Octavius.